3RI3

Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin

3RI3 の概要

• エントリーDOI: 10.2210/pdb3ri3/pdb
• 分子名称: ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, ... (4 entities in total)
• 機能のキーワード: actinorhodin, polyketide, ketoreductase, short-chain dehydrogenase/reductase, rossmann fold, type ii polyketide ketoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Streptomyces coelicolor
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61532.60

構造登録者

Javidpour, P.,Tsai, S.-C. (登録日: 2011-04-12, 公開日: 2011-06-29, 最終更新日: 2023-09-13)

• 主引用文献: Javidpour, P.,Korman, T.P.,Shakya, G.,Tsai, S.C.; Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase.; Biochemistry, 50:4638-4649, 2011; PubMed: 21506596; DOI: 10.1021/bi200335f

実験手法

X-RAY DIFFRACTION (2.292 Å)