3RHK

Crystal structure of the catalytic domain of c-Met kinase in complex with ARQ 197

3RHK の概要

• エントリーDOI: 10.2210/pdb3rhk/pdb
• 分子名称: Hepatocyte growth factor receptor, 1-[(3R,4R)-4-(1H-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium (3 entities in total)
• 機能のキーワード: kinase, receptor tyrosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72714.05

構造登録者

Eathiraj, S.,Palma, R.,Volckova, E.,Hirschi, M.,France, D.S.,Ashwell, M.A.,Chan, T.C. (登録日: 2011-04-11, 公開日: 2011-04-27, 最終更新日: 2024-02-21)

• 主引用文献: Eathiraj, S.,Palma, R.,Volckova, E.,Hirschi, M.,France, D.S.,Ashwell, M.A.,Chan, T.C.; Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197.; J.Biol.Chem., 286:20666-20676, 2011; PubMed: 21454604; DOI: 10.1074/jbc.M110.213801

実験手法

X-RAY DIFFRACTION (1.94 Å)