3RGA

Crystal structure of epoxide hydrolase for polyether lasalocid A biosynthesis

3RGA の概要

• エントリーDOI: 10.2210/pdb3rga/pdb
• 分子名称: Epoxide hydrolase, (4R,5S)-3-[(2R,3S,4S)-2-ethyl-5-[(3R)-2-ethyl-3-[2-[(2R,3R)-2-ethyl-3-methyl-oxiran-2-yl]ethyl]oxiran-2-yl]-3-hydroxy-4-methyl-pentanoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one, (4R,5S)-3-[(2R)-2-{(2S,2'R,4S,5S,5'R)-2,5'-diethyl-5'-[(1S)-1-hydroxyethyl]-4-methyloctahydro-2,2'-bifuran-5-yl}butanoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one, ... (9 entities in total)
• 機能のキーワード: ntf2-like, epoxide-opening cyclic ether formation, isomerase
• 由来する生物種: Streptomyces lasaliensis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31999.47

構造登録者

Hotta, K.,Mathews, I.I.,Chen, X.,Kim, C.-Y. (登録日: 2011-04-08, 公開日: 2012-03-07, 最終更新日: 2023-11-01)

• 主引用文献: Hotta, K.,Chen, X.,Paton, R.S.,Minami, A.,Li, H.,Swaminathan, K.,Mathews, I.I.,Watanabe, K.,Oikawa, H.,Houk, K.N.,Kim, C.-Y.; Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis; Nature, 483:355-358, 2012; PubMed: 22388816; DOI: 10.1038/nature10865

実験手法

X-RAY DIFFRACTION (1.59 Å)