3REW

Crystal structure of an lmp2a-derived peptide bound to human class i mhc hla-a2

Summary for 3REW

Entry DOI	10.2210/pdb3rew/pdb
Related	3REV
Descriptor	HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Latent membrane protein 2, ... (7 entities in total)
Functional Keywords	mhc class i, tumour antigen targeting, immune system, hla-a2, epstein barr virus, alloreactivity, glycoprotein, immune response, mhc i, immunoglobulin domain
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	90333.69
Authors	Wood, A.,Mohammed, F.,Salim, M.,Tranter, A.,Rickinson, A.B.,Moss, P.A.H.,Stauss, H.J.,Steven, N.M.,Willcox, B.E. (deposition date: 2011-04-05, release date: 2012-01-18, Last modification date: 2023-09-13)
Primary citation	Simpson, A.A.,Mohammed, F.,Salim, M.,Tranter, A.,Rickinson, A.B.,Stauss, H.J.,Moss, P.A.,Steven, N.M.,Willcox, B.E. Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction. Proc.Natl.Acad.Sci.USA, 108:21176-21181, 2011 Cited by PubMed: 22160697 DOI: 10.1073/pnas.1108422109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation