3RDH

X-ray induced covalent inhibition of 14-3-3

3RDH の概要

• エントリーDOI: 10.2210/pdb3rdh/pdb
• 分子名称: 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION, ... (4 entities in total)
• 機能のキーワード: phosphoser/thr-mimetic agent, phosphoserine/threonine-recognition protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P63104
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 114053.29

構造登録者

Horton, J.R.,Upadhyay, A.K.,Fu, H.,Cheng, X. (登録日: 2011-04-01, 公開日: 2011-09-28, 最終更新日: 2023-09-13)

• 主引用文献: Zhao, J.,Du, Y.,Horton, J.R.,Upadhyay, A.K.,Lou, B.,Bai, Y.,Zhang, X.,Du, L.,Li, M.,Wang, B.,Zhang, L.,Barbieri, J.T.,Khuri, F.R.,Cheng, X.,Fu, H.; Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.; Proc.Natl.Acad.Sci.USA, 108:16212-16216, 2011; PubMed: 21908710; DOI: 10.1073/pnas.1100012108

実験手法

X-RAY DIFFRACTION (2.39 Å)