3RCH

Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the open conformation with LLP and PLP bound to Chain-A and Chain-B respectively

3RCH の概要

• エントリーDOI: 10.2210/pdb3rch/pdb
• 関連するPDBエントリー: 3RBF 3RBL
• 分子名称: aromatic L-amino acid decarboxylase, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: apo enzyme, apo form, open conformation, open dimer, exposed, conformational change, parkinson, aadc deficiency, ddc, llp, plp, decarboxylase, l-dopa, internal aldimine, shiff base, lyase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 108401.65

構造登録者

Giardina, G.,Montioli, R.,Gianni, S.,Cellini, B.,Paiardini, A.,Borri Voltattorni, C.,Cutruzzola, F. (登録日: 2011-03-31, 公開日: 2011-10-19, 最終更新日: 2023-12-06)

• 主引用文献: Giardina, G.,Montioli, R.,Gianni, S.,Cellini, B.,Paiardini, A.,Voltattorni, C.B.,Cutruzzola, F.; Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.; Proc.Natl.Acad.Sci.USA, 108:20514-20519, 2011; PubMed: 22143761; DOI: 10.1073/pnas.1111456108

実験手法

X-RAY DIFFRACTION (2.8 Å)