3R8I

Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86)

3R8I の概要

• エントリーDOI: 10.2210/pdb3r8i/pdb
• 関連するPDBエントリー: 2I4J 2I4P 2I4Z
• 分子名称: Peroxisome proliferator-activated receptor gamma, 2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]ethyl}phenoxy)-2-methylpropanoic acid (3 entities in total)
• 機能のキーワード: protein-dna complex, bundle of alpha-helices, small four-stranded beta-sheet, transcription, activator, diabetes mellitus, obesity, transcription regulation, dna binding, phosphorylation, nucleus
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65826.21

構造登録者

Pochetti, G.,Montanari, R.,Loiodice, F.,Laghezza, A.,Fracchiolla, G.,Lavecchia, A.,Novellino, E.,Crestani, M. (登録日: 2011-03-24, 公開日: 2012-01-11, 最終更新日: 2023-09-13)

• 主引用文献: Porcelli, L.,Gilardi, F.,Laghezza, A.,Piemontese, L.,Mitro, N.,Azzariti, A.,Altieri, F.,Cervoni, L.,Fracchiolla, G.,Giudici, M.,Guerrini, U.,Lavecchia, A.,Montanari, R.,Di Giovanni, C.,Paradiso, A.,Pochetti, G.,Simone, G.M.,Tortorella, P.,Crestani, M.,Loiodice, F.; Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.; J.Med.Chem., 55:37-54, 2012; PubMed: 22081932; DOI: 10.1021/jm201306q

実験手法

X-RAY DIFFRACTION (2.3 Å)