3R7M

AKR1C3 complex with sulindac

3R7M の概要

• エントリーDOI: 10.2210/pdb3r7m/pdb
• 分子名称: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid, ... (5 entities in total)
• 機能のキーワード: tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P42330
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39201.32

構造登録者

Yosaatmadja, Y.,Teague, R.M.,Flanagan, J.U.,Squire, C.J. (登録日: 2011-03-22, 公開日: 2012-05-02, 最終更新日: 2023-09-13)

• 主引用文献: Flanagan, J.U.,Yosaatmadja, Y.,Teague, R.M.,Chai, M.Z.,Turnbull, A.P.,Squire, C.J.; Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.; Plos One, 7:e43965-e43965, 2012; PubMed: 22937138; DOI: 10.1371/journal.pone.0043965

実験手法

X-RAY DIFFRACTION (2.1 Å)