3R5L

Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824

Summary for 3R5L

• Entry DOI: 10.2210/pdb3r5l/pdb
• Related: 3R5P 3R5R 3R5W 3R5Y 3R5Z
• Descriptor: Deazaflavin-dependent nitroreductase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID (3 entities in total)
• Functional Keywords: pa-824, split barrel-like fold, duf385, deazaflavin-dependent nitroreductase, nitroimidazoles, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 14003.58

Authors

Cellitti, S.E.,Shaffer, J.,Jones, D.H.,Mukherjee, T.,Gurumurthy, M.,Bursulaya, B.,Boshoff, H.I.M.,Choi, I.,Nayyar, A.,Lee, Y.S.,Cherian, J.,Niyomrattanakit, P.,Dick, T.,Manjunatha, U.H.,Barry, C.E.,Spraggon, G.,Geierstanger, B.H. (deposition date: 2011-03-18, release date: 2012-01-18, Last modification date: 2017-11-08)

• Primary citation: Cellitti, S.E.,Shaffer, J.,Jones, D.H.,Mukherjee, T.,Gurumurthy, M.,Bursulaya, B.,Boshoff, H.I.,Choi, I.,Nayyar, A.,Lee, Y.S.,Cherian, J.,Niyomrattanakit, P.,Dick, T.,Manjunatha, U.H.,Barry, C.E.,Spraggon, G.,Geierstanger, B.H.; Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.; Structure, 20:101-112, 2012; PubMed: 22244759; DOI: 10.1016/j.str.2011.11.001

Experimental method

X-RAY DIFFRACTION (1.55 Å)