3R4B
Crystal Structure of Wild-type HIV-1 Protease in Complex With TMC310911
3R4B の概要
エントリーDOI | 10.2210/pdb3r4b/pdb |
分子名称 | HIV-1 protease, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({2-[(1-cyclopentylpiperidin-4-yl)amino]-1,3-benzothiazol-6-yl}sulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-p henylbutan-2-yl}carbamate, PHOSPHATE ION, ... (4 entities in total) |
機能のキーワード | drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Human immunodeficiency virus 1 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 22482.54 |
構造登録者 | |
主引用文献 | Dierynck, I.,Van Marck, H.,Van Ginderen, M.,Jonckers, T.H.,Nalam, M.N.,Schiffer, C.A.,Raoof, A.,Kraus, G.,Picchio, G. TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors. Antimicrob.Agents Chemother., 55:5723-5731, 2011 Cited by PubMed: 21896904DOI: 10.1128/AAC.00748-11 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード