Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein

Summary for 3R2A

DescriptorRetinoic acid receptor RXR-alpha, Nuclear receptor corepressor 2, 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, ... (4 entities in total)
Functional Keywordsnuclear receptor, transcription factor, ligand-binding domain, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P19793 Q9Y618
Total number of polymer chains6
Total molecular weight111490.94
Zhang, H.,Chen, L.,Chen, J.,Jiang, H.,Shen, X. (deposition date: 2011-03-14, release date: 2011-05-25, Last modification date: 2011-07-27)
Primary citation
Zhang, H.,Chen, L.,Chen, J.,Jiang, H.,Shen, X.
Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286:24593-24598, 2011
PubMed: 21613212 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M111.245498
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.278581.2%14.3%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3r2a
no rotation
Molmil generated image of 3r2a
rotated about x axis by 90°
Molmil generated image of 3r2a
rotated about y axis by 90°