3R22
Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)
Summary for 3R22
Entry DOI | 10.2210/pdb3r22/pdb |
Related | 3R21 |
Descriptor | Serine/threonine-protein kinase 6, N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide (3 entities in total) |
Functional Keywords | kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 31748.42 |
Authors | Zhang, L.,Fan, J.,Chong, J.-H.,Cesana, A.,Tam, B.,Gilson, C.,Boykin, C.,Wang, D.,Marcotte, D.,Le Brazidec, J.-Y.,Aivazian, D.,Piao, J.,Lundgren, K.,Hong, K.,Vu, K.,Nguyen, K. (deposition date: 2011-03-11, release date: 2011-08-10, Last modification date: 2023-09-13) |
Primary citation | Zhang, L.,Fan, J.,Chong, J.H.,Cesena, A.,Tam, B.Y.,Gilson, C.,Boykin, C.,Wang, D.,Aivazian, D.,Marcotte, D.,Xiao, G.,Le Brazidec, J.Y.,Piao, J.,Lundgren, K.,Hong, K.,Vu, K.,Nguyen, K.,Gan, L.S.,Silvian, L.,Ling, L.,Teng, M.,Reff, M.,Takeda, N.,Timple, N.,Wang, Q.,Morena, R.,Khan, S.,Zhao, S.,Li, T.,Lee, W.C.,Taveras, A.G.,Chao, J. Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I). Bioorg.Med.Chem.Lett., 21:5633-5637, 2011 Cited by PubMed: 21798738DOI: 10.1016/j.bmcl.2011.06.129 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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