3R21

Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)

3R21 の概要

• エントリーDOI: 10.2210/pdb3r21/pdb
• 関連するPDBエントリー: 3R22
• 分子名称: Serine/threonine-protein kinase 6, N-(2-aminoethyl)-N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, centrosome: O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31815.80

構造登録者

Zhang, L.,Fan, J.,Chong, J.-H.,Cesena, A.,Tam, B.,Gilson, C.,Boykin, C.,Wang, D.,Marcotte, D.,Le Brazidec, J.-Y.,Aivazian, D.,Piao, J.,Lundgren, K.,Hong, K.,Vu, K.,Nguyen, K. (登録日: 2011-03-11, 公開日: 2011-08-10, 最終更新日: 2023-09-13)

• 主引用文献: Zhang, L.,Fan, J.,Chong, J.H.,Cesena, A.,Tam, B.Y.,Gilson, C.,Boykin, C.,Wang, D.,Aivazian, D.,Marcotte, D.,Xiao, G.,Le Brazidec, J.Y.,Piao, J.,Lundgren, K.,Hong, K.,Vu, K.,Nguyen, K.,Gan, L.S.,Silvian, L.,Ling, L.,Teng, M.,Reff, M.,Takeda, N.,Timple, N.,Wang, Q.,Morena, R.,Khan, S.,Zhao, S.,Li, T.,Lee, W.C.,Taveras, A.G.,Chao, J.; Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).; Bioorg.Med.Chem.Lett., 21:5633-5637, 2011; PubMed: 21798738; DOI: 10.1016/j.bmcl.2011.06.129

実験手法

X-RAY DIFFRACTION (2.9 Å)