3R1B

Open crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene

Summary for 3R1B

Entry DOI	10.2210/pdb3r1b/pdb
Related	3R1A
Related PRD ID	PRD_900003
Descriptor	Cytochrome P450 2B4, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
Functional Keywords	cytochrome p450 2b4, monooxygenase, membrane protein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
Total number of polymer chains	4
Total formula weight	223689.35
Authors	Gay, S.C.,Zhang, H.,Stout, C.D.,Hollenberg, P.F.,Halpert, J.R. (deposition date: 2011-03-09, release date: 2011-05-11, Last modification date: 2023-09-13)
Primary citation	Gay, S.C.,Zhang, H.,Wilderman, P.R.,Roberts, A.G.,Liu, T.,Li, S.,Lin, H.L.,Zhang, Q.,Woods, V.L.,Stout, C.D.,Hollenberg, P.F.,Halpert, J.R. Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity. Biochemistry, 50:4903-4911, 2011 Cited by PubMed: 21510666 DOI: 10.1021/bi200482g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation