3R1B

Open crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene

3R1B の概要

• エントリーDOI: 10.2210/pdb3r1b/pdb
• 関連するPDBエントリー: 3R1A
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: Cytochrome P450 2B4, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: cytochrome p450 2b4, monooxygenase, membrane protein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 223689.35

構造登録者

Gay, S.C.,Zhang, H.,Stout, C.D.,Hollenberg, P.F.,Halpert, J.R. (登録日: 2011-03-09, 公開日: 2011-05-11, 最終更新日: 2023-09-13)

• 主引用文献: Gay, S.C.,Zhang, H.,Wilderman, P.R.,Roberts, A.G.,Liu, T.,Li, S.,Lin, H.L.,Zhang, Q.,Woods, V.L.,Stout, C.D.,Hollenberg, P.F.,Halpert, J.R.; Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity.; Biochemistry, 50:4903-4911, 2011; PubMed: 21510666; DOI: 10.1021/bi200482g

実験手法

X-RAY DIFFRACTION (3 Å)