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3R04

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

Summary for 3R04
Entry DOI10.2210/pdb3r04/pdb
Related3R00 3R01 3R02
DescriptorProto-oncogene serine/threonine-protein kinase pim-1, 5-{6-[(trans-4-aminocyclohexyl)amino]pyrazin-2-yl}-1-benzofuran-2-carboxylic acid, IMIDAZOLE, ... (4 entities in total)
Functional Keywordskinae, pim1, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationIsoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains1
Total formula weight35040.74
Authors
Xiang, Y.,Hirth, B.,Asmussen, G.,Biemann, H.-P.,Good, A.,Fitzgerald, M.,Gladysheva, T.,Jancsics, K.,Liu, J.,Metz, M.,Papoulis, A.,Skerlj, R.,Stepp, D.J.,Wei, R.R. (deposition date: 2011-03-07, release date: 2011-05-11, Last modification date: 2024-02-21)
Primary citationXiang, Y.,Hirth, B.,Asmussen, G.,Biemann, H.P.,Bishop, K.A.,Good, A.,Fitzgerald, M.,Gladysheva, T.,Jain, A.,Jancsics, K.,Liu, J.,Metz, M.,Papoulis, A.,Skerlj, R.,Stepp, J.D.,Wei, R.R.
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Bioorg.Med.Chem.Lett., 21:3050-3056, 2011
Cited by
PubMed: 21507633
DOI: 10.1016/j.bmcl.2011.03.030
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

數據於2024-03-27公開中

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