3R01
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
Summary for 3R01
Entry DOI | 10.2210/pdb3r01/pdb |
Related | 3R00 3R02 3R04 |
Descriptor | Proto-oncogene serine/threonine-protein kinase pim-1, IMIDAZOLE, 5-bromo-7-methoxy-1-benzofuran-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | kinase, pim1, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 34890.33 |
Authors | |
Primary citation | Xiang, Y.,Hirth, B.,Asmussen, G.,Biemann, H.P.,Bishop, K.A.,Good, A.,Fitzgerald, M.,Gladysheva, T.,Jain, A.,Jancsics, K.,Liu, J.,Metz, M.,Papoulis, A.,Skerlj, R.,Stepp, J.D.,Wei, R.R. The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Bioorg.Med.Chem.Lett., 21:3050-3056, 2011 Cited by PubMed: 21507633DOI: 10.1016/j.bmcl.2011.03.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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