3QYL

Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate

Summary for 3QYL

Entry DOI	10.2210/pdb3qyl/pdb
Related	3QYO
Descriptor	Dihydrofolate reductase, (7S)-7-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	rossmann fold, reductase, oxidoreductase
Biological source	Escherichia coli K-12
Total number of polymer chains	1
Total formula weight	19059.59
Authors	Collins, E.J.,Lee, A.L.,Carroll, M.J.,Mauldin, R.V.,Gromova, A.V.,Singleton, S.F. (deposition date: 2011-03-03, release date: 2012-01-18, Last modification date: 2024-02-21)
Primary citation	Carroll, M.J.,Mauldin, R.V.,Gromova, A.V.,Singleton, S.F.,Collins, E.J.,Lee, A.L. Evidence for dynamics in proteins as a mechanism for ligand dissociation. Nat.Chem.Biol., 8:246-252, 2012 Cited by PubMed: 22246400 DOI: 10.1038/nchembio.769 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation