3QX3

Human topoisomerase IIbeta in complex with DNA and etoposide

Summary for 3QX3

Related3QXK
DescriptorDNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (6 entities in total)
Functional Keywordstoprim domain, winged-helix domain, coiled-coil domain, dna binding and cleavage, nucleus, isomerase-dna-isomerase inhibitor complex, isomerase/dna/isomerase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm Q02880
Total number of polymer chains6
Total molecular weight197361.67
Authors
Wu, C.C.,Li, T.K.,Farh, L.,Lin, L.Y.,Lin, T.S.,Yu, Y.J.,Yen, T.J.,Chiang, C.W.,Chan, N.L. (deposition date: 2011-03-01, release date: 2011-07-06, Last modification date: 2012-01-25)
Primary citation
Wu, C.C.,Li, T.K.,Farh, L.,Lin, L.Y.,Lin, T.S.,Yu, Y.J.,Yen, T.J.,Chiang, C.W.,Chan, N.L.
Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
Science, 333:459-462, 2011
PubMed: 21778401 (PDB entries with the same primary citation)
DOI: 10.1126/science.1204117
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.162 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20480.2%0.8%5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution