3QW4

Structure of Leishmania donovani UMP synthase

Summary for 3QW4

• Entry DOI: 10.2210/pdb3qw4/pdb
• Descriptor: UMP synthase, URIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: n-terminal orotidine monophosphate decarboxylase domain c-terminal orotate phosphoribosyltransferase domain, transferase, lyase
• Biological source: Leishmania donovani
• Total number of polymer chains: 2
• Total formula weight: 99587.25

Authors

French, J.B.,Ealick, S.E. (deposition date: 2011-02-26, release date: 2011-04-20, Last modification date: 2024-02-21)

• Primary citation: French, J.B.,Yates, P.A.,Soysa, D.R.,Boitz, J.M.,Carter, N.S.,Chang, B.,Ullman, B.,Ealick, S.E.; The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization.; J.Biol.Chem., 286:20930-20941, 2011; PubMed: 21507942; DOI: 10.1074/jbc.M111.228213

Experimental method

X-RAY DIFFRACTION (3 Å)