3QW1

Crystal structure of the Zn-RIDC1 complex stabilized by BMH crosslinks

Summary for 3QW1

Entry DOI	10.2210/pdb3qw1/pdb
Related	3HNI 3IQ6 3QVY 3QVZ 3QW0
Descriptor	Cytochrome cb562, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
Functional Keywords	four-helix bundle, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	4
Total formula weight	50226.15
Authors	Salgado, E.N.,Tezcan, F.A. (deposition date: 2011-02-26, release date: 2011-06-22, Last modification date: 2024-11-06)
Primary citation	Salgado, E.N.,Brodin, J.D.,To, M.M.,Tezcan, F.A. Templated construction of a zn-selective protein dimerization motif. Inorg.Chem., 50:6323-6329, 2011 Cited by PubMed Abstract: Here, we report that the approach of metal-templated ligand synthesis can be applied to construct a dimeric protein assembly ((BMOE)RIDC1(2)), which is stabilized by noncovalent interactions and flexible covalent cross-linkers around the Zn templates. Despite its flexibility, (BMOE)RIDC1(2) selectively binds Zn(II) over other divalent metals and undergoes dimerization upon metal binding. Such simultaneous fulfillment of plasticity and selectivity is a hallmark of cellular signaling events that involve ligand/metal-induced protein dimerization. PubMed: 21648390 DOI: 10.1021/ic200746m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation