3QW0

Crystal structure of the Zn-RIDC1 complex stabilized by BMB crosslinks

3QW0 の概要

• エントリーDOI: 10.2210/pdb3qw0/pdb
• 関連するPDBエントリー: 3HNI 3IQ6 3QVY 3QVZ 3QW1
• 分子名称: Cytochrome cb562, PROTOPORPHYRIN IX CONTAINING FE, 1,1'-butane-1,4-diylbis(1H-pyrrole-2,5-dione), ... (6 entities in total)
• 機能のキーワード: four-helix bundle, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 50623.23

構造登録者

Salgado, E.N.,Tezcan, F.A. (登録日: 2011-02-26, 公開日: 2011-06-22, 最終更新日: 2024-11-27)

主引用文献

Salgado, E.N.,Brodin, J.D.,To, M.M.,Tezcan, F.A.
Templated construction of a zn-selective protein dimerization motif.
Inorg.Chem., 50:6323-6329, 2011

PubMed Abstract: Here, we report that the approach of metal-templated ligand synthesis can be applied to construct a dimeric protein assembly ((BMOE)RIDC1(2)), which is stabilized by noncovalent interactions and flexible covalent cross-linkers around the Zn templates. Despite its flexibility, (BMOE)RIDC1(2) selectively binds Zn(II) over other divalent metals and undergoes dimerization upon metal binding. Such simultaneous fulfillment of plasticity and selectivity is a hallmark of cellular signaling events that involve ligand/metal-induced protein dimerization.

PubMed: 21648390
DOI: 10.1021/ic200746m

実験手法

X-RAY DIFFRACTION (1.84 Å)