3QUD

Human p38 MAP Kinase in Complex with 2-amino-phenylamino-benzophenone

3QUD の概要

• エントリーDOI: 10.2210/pdb3qud/pdb
• 関連するPDBエントリー: 3QUE
• 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, {4-[(2-aminophenyl)amino]phenyl}(phenyl)methanone, ... (4 entities in total)
• 機能のキーワード: kinase domain, phosphate transferase, benzophenone derivative, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42142.14

構造登録者

Gruetter, C.,Rauh, D. (登録日: 2011-02-23, 公開日: 2012-04-11, 最終更新日: 2023-11-01)

• 主引用文献: Karcher, S.C.,Fischer, S.,Schattel, V.,Romir, J.,Stehle, T.,Gruetter, C.,Rauh, D.,Laufer, S.A.; Resolving the selectivity problem for p38 mitogen activated protein (MAP) Kinase-inhibitors: Development of new highly potent inhibitors of p38 MAP kinase with an outstanding selectivity profile; To be Published,

実験手法

X-RAY DIFFRACTION (2 Å)