3QTK

The crystal structure of chemically synthesized VEGF-A

3QTK の概要

• エントリーDOI: 10.2210/pdb3qtk/pdb
• 分子名称: Vascular endothelial growth factor A, ACETATE ION, trifluoroacetic acid, ... (5 entities in total)
• 機能のキーワード: covalent dimer, cysteine knot protein, growth factor, x-ray crystal structure, human vegf-a, hormone
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P15692
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 73216.95

構造登録者

Mandal, K.,Kent, S.B.H. (登録日: 2011-02-22, 公開日: 2011-07-27, 最終更新日: 2024-10-16)

主引用文献

Mandal, K.,Kent, S.B.
Total chemical synthesis of biologically active vascular endothelial growth factor.
Angew.Chem.Int.Ed.Engl., 50:8029-8033, 2011

PubMed Abstract: Efficient access: the 204-residue covalent-dimer vascular endothelial growth factor with full mitogenic activity was prepared from three unprotected peptide segments by one-pot native chemical ligations. The covalent structure of the synthetic VEGF was confirmed by precise mass measurement, and the three-dimensional structure of the synthetic protein was determined by high-resolution X-ray crystallography.

PubMed: 21744452
DOI: 10.1002/anie.201103237

実験手法

X-RAY DIFFRACTION (1.849 Å)