3QTF
Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity
Summary for 3QTF
Entry DOI | 10.2210/pdb3qtf/pdb |
Descriptor | Heat shock protein HSP 90-alpha, (6S)-6,15,15,18-tetramethyl-17-oxo-2,3,4,5,6,7,14,15,16,17-decahydro-1H-8,12-(metheno)[1,4,9]triazacyclotetradecino[9,8-a]indole-9-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | chaperone, atp binding domain, atp-binding, nucleotide-binding, phosphoprotein, stress response, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 25899.24 |
Authors | Zapf, C.W.,Bloom, J.D.,McBean, J.L.,Dushin, R.G.,Nittoli, T.,Ingalls, C.,Sutherland, A.G.,Sonye, J.P.,Eid, C.N.,Golas, J.,Liu, H.,Boschelli, F.,Hu, Y.,Vogan, E.M.,Levin, J.I. (deposition date: 2011-02-22, release date: 2011-04-06, Last modification date: 2024-02-21) |
Primary citation | Zapf, C.W.,Bloom, J.D.,McBean, J.L.,Dushin, R.G.,Nittoli, T.,Ingalls, C.,Sutherland, A.G.,Sonye, J.P.,Eid, C.N.,Golas, J.,Liu, H.,Boschelli, F.,Hu, Y.,Vogan, E.,Levin, J.I. Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity. Bioorg.Med.Chem.Lett., 21:2278-2282, 2011 Cited by PubMed: 21420297DOI: 10.1016/j.bmcl.2011.02.101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5703 Å) |
Structure validation
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