3QSD

Structure of cathepsin B1 from Schistosoma mansoni in complex with CA074 inhibitor

3QSD の概要

• エントリーDOI: 10.2210/pdb3qsd/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001032
• 分子名称: Cathepsin B-like peptidase (C01 family), [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: cysteine peptidase, digestive tract, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Schistosoma mansoni (Blood fluke)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29116.92

構造登録者

Rezacova, P.,Jilkova, A.,Brynda, J.,Horn, M.,Mares, M. (登録日: 2011-02-21, 公開日: 2011-08-10, 最終更新日: 2023-09-13)

• 主引用文献: Jilkova, A.,Rezacova, P.,Lepsik, M.,Horn, M.,Vachova, J.,Fanfrlik, J.,Brynda, J.,McKerrow, J.H.,Caffrey, C.R.,Mares, M.; Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni.; J.Biol.Chem., 286:35770-35781, 2011; PubMed: 21832058; DOI: 10.1074/jbc.M111.271304

実験手法

X-RAY DIFFRACTION (1.3 Å)