3QQU

Cocrystal structure of unphosphorylated igf with pyrimidine 8

3QQU の概要

• エントリーDOI: 10.2210/pdb3qqu/pdb
• 分子名称: Insulin-like growth factor 1 receptor, N~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-N~4~-(quinolin-3-yl)pyrimidine-2,4-diamine (3 entities in total)
• 機能のキーワード: igf, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08069
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 139107.60

構造登録者

Huang, X. (登録日: 2011-02-16, 公開日: 2011-04-20, 最終更新日: 2024-02-21)

主引用文献

Buchanan, J.L.,Newcomb, J.R.,Carney, D.P.,Chaffee, S.C.,Chai, L.,Cupples, R.,Epstein, L.F.,Gallant, P.,Gu, Y.,Harmange, J.C.,Hodge, K.,Houk, B.E.,Huang, X.,Jona, J.,Joseph, S.,Jun, H.T.,Kumar, R.,Li, C.,Lu, J.,Menges, T.,Morrison, M.J.,Novak, P.M.,van der Plas, S.,Radinsky, R.,Rose, P.E.,Sawant, S.,Sun, J.R.,Surapaneni, S.,Turci, S.M.,Xu, K.,Yanez, E.,Zhao, H.,Zhu, X.
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Bioorg.Med.Chem.Lett., 21:2394-2399, 2011

PubMed Abstract: The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to be an appealing target for the treatment of human cancer. Herein, we report the synthesis, structure-activity relationships (SAR), X-ray cocrystal structure and in vivo tumor study results for a series of 2,4-bis-arylamino-1,3-pyrimidines.

PubMed: 21414779
DOI: 10.1016/j.bmcl.2011.02.075

実験手法

X-RAY DIFFRACTION (2.9 Å)