3QNF

Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1

Summary for 3QNF

• Entry DOI: 10.2210/pdb3qnf/pdb
• Related: 2XDT
• Descriptor: Endoplasmic reticulum aminopeptidase 1, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• Functional Keywords: structural genomics consortium, sgc, glycoprotein, metal-binding, metalloprotease, protease, adaptive immunity, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 329044.22

Authors

Vollmar, M.,Kochan, G.,Krojer, T.,Harvey, D.,Chaikuad, A.,Allerston, C.,Muniz, J.R.C.,Raynor, J.,Ugochukwu, E.,Berridge, G.,Wordsworth, B.P.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Kavanagh, K.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2011-02-08, release date: 2011-02-23, Last modification date: 2023-09-13)

• Primary citation: Kochan, G.,Krojer, T.,Harvey, D.,Fischer, R.,Chen, L.,Vollmar, M.,von Delft, F.,Kavanagh, K.L.,Brown, M.A.,Bowness, P.,Wordsworth, P.,Kessler, B.M.,Oppermann, U.; Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.; Proc.Natl.Acad.Sci.USA, 108:7745-7750, 2011; PubMed: 21508329; DOI: 10.1073/pnas.1101262108

Experimental method

X-RAY DIFFRACTION (3 Å)