3QMK

Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide

3QMK の概要

• エントリーDOI: 10.2210/pdb3qmk/pdb
• 分子名称: Amyloid-like protein 1, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: app, alzheimer's disease, cellular adhesion, heparin, brain, cell adhesion
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. C30: Cytoplasm: P51693
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51137.16

構造登録者

Xue, Y.,Ha, Y. (登録日: 2011-02-04, 公開日: 2011-10-12, 最終更新日: 2024-02-21)

• 主引用文献: Xue, Y.,Lee, S.,Ha, Y.; Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization.; Proc.Natl.Acad.Sci.USA, 108:16229-16234, 2011; PubMed: 21930949; DOI: 10.1073/pnas.1103407108

実験手法

X-RAY DIFFRACTION (2.21 Å)