3QI5

Crystal structure of human alkyladenine DNA glycosylase in complex with 3,N4-ethenocystosine containing duplex DNA

3QI5 の概要

• エントリーDOI: 10.2210/pdb3qi5/pdb
• 分子名称: DNA-3-methyladenine glycosylase, DNA (5'-D(*GP*AP*CP*AP*TP*GP*(EDC)P*TP*TP*GP*CP*CP*T)-3'), DNA (5'-D(*GP*GP*CP*AP*AP*GP*CP*AP*TP*GP*TP*CP*A)-3'), ... (5 entities in total)
• 機能のキーワード: alkyladenine dna glycosylase fold, aag, excision, dna repair, dna binding, nucleus, hydrolase-dna complex, hydrolase/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (Potential): P29372
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 64674.09

構造登録者

Lingaraju, G.M.,Davis, C.A.,Setser, J.W.,Samson, L.D.,Drennan, C.L. (登録日: 2011-01-26, 公開日: 2011-03-09, 最終更新日: 2023-09-13)

• 主引用文献: Lingaraju, G.M.,Davis, C.A.,Setser, J.W.,Samson, L.D.,Drennan, C.L.; Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N4-Ethenocytosine-containing DNA.; J.Biol.Chem., 286:13205-13213, 2011; PubMed: 21349833; DOI: 10.1074/jbc.M110.192435

実験手法

X-RAY DIFFRACTION (2.2 Å)