3QI4

Crystal structure of PDE9A(Q453E) in complex with IBMX

Summary for 3QI4

• Entry DOI: 10.2210/pdb3qi4/pdb
• Related: 3QI3
• Descriptor: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, 3-ISOBUTYL-1-METHYLXANTHINE, ZINC ION, ... (5 entities in total)
• Functional Keywords: pde, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform PDE9A1: Cell projection, ruffle membrane. Isoform PDE9A2: Cell projection, ruffle membrane. Isoform PDE9A3: Cytoplasm. Isoform PDE9A17: Cytoplasm: O76083
• Total number of polymer chains: 2
• Total formula weight: 124204.04

Authors

Hou, J.,Xu, J.,Liu, M.,Zhao, R.,Lou, H.,Ke, H. (deposition date: 2011-01-26, release date: 2011-04-27, Last modification date: 2024-02-21)

• Primary citation: Hou, J.,Xu, J.,Liu, M.,Zhao, R.,Luo, H.B.,Ke, H.; Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic Acid, and role of the invariant glutamine.; Plos One, 6:e18092-e18092, 2011; PubMed: 21483814; DOI: 10.1371/journal.pone.0018092

Experimental method

X-RAY DIFFRACTION (2.5 Å)