3QGZ

Re-investigated high resolution crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from rabbit complexed with adenosine

「3LLJ」から置き換えられました

3QGZ の概要

• エントリーDOI: 10.2210/pdb3qgz/pdb
• 関連するPDBエントリー: 1RZY 3LLJ 3RHN 4RHN 5RHN 6RHN
• 分子名称: Histidine triad nucleotide-binding protein 1, ADENOSINE (3 entities in total)
• 機能のキーワード: hint protein, hit family protein, hydrolase, adenosine 5'-monophosphoramidase
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• 細胞内の位置: Cytoplasm: P80912
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13981.08

構造登録者

Dolot, R.M.,Ozga, M.,Krakowiak, A.,Nawrot, B.,Stec, W.J. (登録日: 2011-01-25, 公開日: 2011-02-16, 最終更新日: 2023-09-13)

主引用文献

Dolot, R.,Ozga, M.,Krakowiak, A.,Nawrot, B.
High-resolution X-ray crystal structure of rabbit histidine triad nucleotide-binding protein 1 (rHINT1) - adenosine complex at 1.10A resolution
Acta Crystallogr.,Sect.D, 67:601-607, 2011

PubMed Abstract: Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch in the histidine-triad protein superfamily. HINT1 plays an important role in various biological processes and has been found in many species. Here, the first complete structure of the rabbit HINT1-adenosine complex is reported at 1.10 Å resolution, which is one of the highest resolutions obtained for a HINT1 structure. The final structure has an R(cryst) of 14.25% (R(free) = 16.77%) and the model exhibits good stereochemical qualities. A detailed analysis of the atomic resolution data allowed an update of the details of the protein structure in comparison to previously published data.

PubMed: 21697598
DOI: 10.1107/S0907444911015605

実験手法

X-RAY DIFFRACTION (1.1 Å)