3QDD

HSP90A N-terminal domain in complex with BIIB021

Summary for 3QDD

Entry DOI	10.2210/pdb3qdd/pdb
Descriptor	Heat shock protein HSP 90-alpha, 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine (3 entities in total)
Functional Keywords	atpase, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	27058.68
Authors	Arndt, J.W.,Biamonte, M.A. (deposition date: 2011-01-18, release date: 2012-07-18, Last modification date: 2022-10-05)
Primary citation	Shi, J.,Van de Water, R.,Hong, K.,Lamer, R.B.,Weichert, K.W.,Sandoval, C.M.,Kasibhatla, S.R.,Boehm, M.F.,Chao, J.,Lundgren, K.,Timple, N.,Lough, R.,Ibanez, G.,Boykin, C.,Burrows, F.J.,Kehry, M.R.,Yun, T.J.,Harning, E.K.,Ambrose, C.,Thompson, J.,Bixler, S.A.,Dunah, A.,Snodgrass-Belt, P.,Arndt, J.,Enyedy, I.J.,Li, P.,Hong, V.S.,McKenzie, A.,Biamonte, M.A. EC144 Is a Potent Inhibitor of the Heat Shock Protein 90. J.Med.Chem., 55:7786-7795, 2012 Cited by PubMed: 22938030 DOI: 10.1021/jm300810x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation