3QDD

HSP90A N-terminal domain in complex with BIIB021

3QDD の概要

• エントリーDOI: 10.2210/pdb3qdd/pdb
• 分子名称: Heat shock protein HSP 90-alpha, 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine (3 entities in total)
• 機能のキーワード: atpase, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27058.68

構造登録者

Arndt, J.W.,Biamonte, M.A. (登録日: 2011-01-18, 公開日: 2012-07-18, 最終更新日: 2024-05-22)

• 主引用文献: Shi, J.,Van de Water, R.,Hong, K.,Lamer, R.B.,Weichert, K.W.,Sandoval, C.M.,Kasibhatla, S.R.,Boehm, M.F.,Chao, J.,Lundgren, K.,Timple, N.,Lough, R.,Ibanez, G.,Boykin, C.,Burrows, F.J.,Kehry, M.R.,Yun, T.J.,Harning, E.K.,Ambrose, C.,Thompson, J.,Bixler, S.A.,Dunah, A.,Snodgrass-Belt, P.,Arndt, J.,Enyedy, I.J.,Li, P.,Hong, V.S.,McKenzie, A.,Biamonte, M.A.; EC144 Is a Potent Inhibitor of the Heat Shock Protein 90.; J.Med.Chem., 55:7786-7795, 2012; PubMed: 22938030; DOI: 10.1021/jm300810x

実験手法

X-RAY DIFFRACTION (1.79 Å)