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3QCQ

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-(3-Amino-1H-indazol-6-yl)-N4-ethyl-2,4-pyrimidinediamine

3QCQ の概要
エントリーDOI10.2210/pdb3qcq/pdb
関連するPDBエントリー3NUN 3NUS 3NUU 3NUY 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4
分子名称3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... (5 entities in total)
機能のキーワードprotein-ligand complex, kinase, signal transduction, atp binding phosphoinositide binding for full length, phoshorylation on s241, celluar and membrane associated, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm: O15530
タンパク質・核酸の鎖数1
化学式量合計36578.72
構造登録者
主引用文献Medina, J.R.,Becker, C.J.,Blackledge, C.W.,Duquenne, C.,Feng, Y.,Grant, S.W.,Heerding, D.,Li, W.H.,Miller, W.H.,Romeril, S.P.,Scherzer, D.,Shu, A.,Bobko, M.A.,Chadderton, A.R.,Dumble, M.,Gardiner, C.M.,Gilbert, S.,Liu, Q.,Rabindran, S.K.,Sudakin, V.,Xiang, H.,Brady, P.G.,Campobasso, N.,Ward, P.,Axten, J.M.
Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors.
J.Med.Chem., 54:1871-1895, 2011
Cited by
PubMed: 21341675
DOI: 10.1021/jm101527u
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.501 Å)
構造検証レポート
Validation report summary of 3qcq
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-05-01に公開中

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