3QCQ
Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-(3-Amino-1H-indazol-6-yl)-N4-ethyl-2,4-pyrimidinediamine
3QCQ の概要
エントリーDOI | 10.2210/pdb3qcq/pdb |
関連するPDBエントリー | 3NUN 3NUS 3NUU 3NUY 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 |
分子名称 | 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... (5 entities in total) |
機能のキーワード | protein-ligand complex, kinase, signal transduction, atp binding phosphoinositide binding for full length, phoshorylation on s241, celluar and membrane associated, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: O15530 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 36578.72 |
構造登録者 | Medina, J.R.,Becker, C.J.,Blackledge, C.W.,Duquenne, C.,Feng, Y.,Grant, S.W.,Heerding, D.,Li, W.H.,Miller, W.H.,Romeril, S.P.,Scherzer, D.,Shu, A.,Bobko, M.A.,Chadderton, A.R.,Dumble, M.,Gradiner, C.M.,Gilbert, S.,Liu, Q.,Rabindran, S.K.,Sudakin, V.,Xiang, H.,Brady, P.G.,Campobasso, N.,Ward, P.,Axten, J.M. (登録日: 2011-01-17, 公開日: 2011-03-09, 最終更新日: 2011-07-13) |
主引用文献 | Medina, J.R.,Becker, C.J.,Blackledge, C.W.,Duquenne, C.,Feng, Y.,Grant, S.W.,Heerding, D.,Li, W.H.,Miller, W.H.,Romeril, S.P.,Scherzer, D.,Shu, A.,Bobko, M.A.,Chadderton, A.R.,Dumble, M.,Gardiner, C.M.,Gilbert, S.,Liu, Q.,Rabindran, S.K.,Sudakin, V.,Xiang, H.,Brady, P.G.,Campobasso, N.,Ward, P.,Axten, J.M. Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54:1871-1895, 2011 Cited by PubMed: 21341675DOI: 10.1021/jm101527u 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.501 Å) |
構造検証レポート
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