3QBF

HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor

3QBF の概要

• エントリーDOI: 10.2210/pdb3qbf/pdb
• 関連するPDBエントリー: 2QNN
• 分子名称: Protease, 4-{(3-phenylpropyl)[(3S,4S)-4-{[4-(trifluoromethyl)benzyl]amino}pyrrolidin-3-yl]sulfamoyl}benzamide, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22552.89

構造登録者

Lindemann, I.,Heine, A.,Klebe, G. (登録日: 2011-01-13, 公開日: 2012-01-18, 最終更新日: 2023-11-01)

• 主引用文献: Lindemann, I.,Klee, N.,Heine, A.,Diederich, W.E.,Klebe, G.; Design of a series of novel three-armed pyrrolidine-based inhibitors for HIV-1 protease; To be Published,

実験手法

X-RAY DIFFRACTION (1.45 Å)