3Q61

3'-Fluoro Hexitol Nucleic Acid DNA Structure

3Q61 の概要

• エントリーDOI: 10.2210/pdb3q61/pdb
• 分子名称: DNA (5'-D(*GP*CP*GP*TP*AP*(F3H)P*AP*CP*GP*C)-3') (2 entities in total)
• 機能のキーワード: a-form dna, 3'-fluoro hexitol nucleic acid, fhna, antisense oligonucleotides, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 6154.05

構造登録者

Seth, P.R.,Allerson, C.R.,Prakash, T.P.,Siwkowski, A.,Berdeja, A.,Yu, J.,Pallan, P.S.,Watt, A.T.,Gaus, H.,Bhat, B.,Egli, M.,Swayze, E.E. (登録日: 2010-12-30, 公開日: 2012-01-18, 最終更新日: 2023-09-13)

• 主引用文献: Egli, M.,Pallan, P.S.,Allerson, C.R.,Prakash, T.P.,Berdeja, A.,Yu, J.,Lee, S.,Watt, A.,Gaus, H.,Bhat, B.,Swayze, E.E.,Seth, P.P.; Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.; J.Am.Chem.Soc., 133:16642-16649, 2011; PubMed: 21919455; DOI: 10.1021/ja207086x

実験手法

X-RAY DIFFRACTION (1.56 Å)