3Q5L

Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K 213 in the presence of 17-AEP-geldanamycin

Summary for 3Q5L

• Entry DOI: 10.2210/pdb3q5l/pdb
• Related: 3H80 3Q5I 3Q5J 3Q5L
• Descriptor: Heat shock protein 83-1, (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-{[2-(pyrrolidin-1-yl)ethyl]amino}-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate (2 entities in total)
• Functional Keywords: sleeping sickness, leishmania, heat shock protein, structural genomics, structural genomics consortium, sgc, chaperone
• Biological source: Leishmania major
• Total number of polymer chains: 4
• Total formula weight: 107012.99

Authors

Wernimont, A.K.,Tempel, W.,Lin, Y.H.,Hutchinson, A.,MacKenzie, F.,Fairlamb, A.,Cossar, D.,Zhao, Y.,Schapira, M.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Ferguson, M.A.J.,Hui, R.,Pizarro, J.C.,Hills, T.,Structural Genomics Consortium (SGC) (deposition date: 2010-12-28, release date: 2011-02-23, Last modification date: 2023-09-13)

• Primary citation: Wernimont, A.K.,Tempel, W.,Lin, Y.H.,Hutchinson, A.,MacKenzie, F.,Fairlamb, A.,Cossar, D.,Zhao, Y.,Schapira, M.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Ferguson, M.A.J.,Hui, R.,Pizarro, J.C.,Hills, T.; Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K 213 in the presence of 17-AEP-geldanamycin.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.65 Å)