3Q4C

Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292

Summary for 3Q4C

• Entry DOI: 10.2210/pdb3q4c/pdb
• Descriptor: Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+) (2 entities in total)
• Functional Keywords: kinase, inhibitor, oncoprotein, melanoma, kinase-kinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): P15056
• Total number of polymer chains: 2
• Total formula weight: 70994.20

Authors

Xie, P.,Streu, C.,Qin, J.,Pregman, H.,Pagano, N.,Meggers, E.,Marmorstein, R. (deposition date: 2010-12-23, release date: 2011-03-02, Last modification date: 2024-02-21)

• Primary citation: Xie, P.,Streu, C.,Qin, J.,Bregman, H.,Pagano, N.,Meggers, E.,Marmorstein, R.; The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.; Biochemistry, 48:5187-5198, 2009; PubMed: 19371126; DOI: 10.1021/bi802067u

Experimental method

X-RAY DIFFRACTION (3.2 Å)