3Q4C
Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292
3Q4C の概要
エントリーDOI | 10.2210/pdb3q4c/pdb |
分子名称 | Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+) (2 entities in total) |
機能のキーワード | kinase, inhibitor, oncoprotein, melanoma, kinase-kinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus (By similarity): P15056 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 70994.20 |
構造登録者 | Xie, P.,Streu, C.,Qin, J.,Pregman, H.,Pagano, N.,Meggers, E.,Marmorstein, R. (登録日: 2010-12-23, 公開日: 2011-03-02, 最終更新日: 2024-02-21) |
主引用文献 | Xie, P.,Streu, C.,Qin, J.,Bregman, H.,Pagano, N.,Meggers, E.,Marmorstein, R. The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. Biochemistry, 48:5187-5198, 2009 Cited by PubMed: 19371126DOI: 10.1021/bi802067u 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.2 Å) |
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