3Q3Y
Complex structure of HEVB EV93 main protease 3C with Compound 1 (AG7404)
Summary for 3Q3Y
Entry DOI | 10.2210/pdb3q3y/pdb |
Related | 3Q3X |
Descriptor | HEVB EV93 3C protease, ethyl (4R)-4-({(2S)-2-[3-{[(5-methyl-1,2-oxazol-3-yl)carbonyl]amino}-2-oxopyridin-1(2H)-yl]pent-4-ynoyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | cysteine trypsin-like protease, 3c cysteine protease (picornain 3c), antiviral compound 1 (ag7404), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human enterovirus B |
Total number of polymer chains | 2 |
Total formula weight | 44662.69 |
Authors | Costenaro, L.,Kaczmarska, Z.,Arnan, C.,Sola, M.,Coutard, B.,Norder, H.,Canard, B.,Coll, M. (deposition date: 2010-12-22, release date: 2011-09-07, Last modification date: 2023-09-13) |
Primary citation | Costenaro, L.,Kaczmarska, Z.,Arnan, C.,Janowski, R.,Coutard, B.,Sola, M.,Gorbalenya, A.E.,Norder, H.,Canard, B.,Coll, M. Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93. J.Virol., 85:10764-10773, 2011 Cited by PubMed: 21835784DOI: 10.1128/JVI.05062-11 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.32 Å) |
Structure validation
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