3Q3K
Factor Xa in complex with a phenylenediamine derivative
Summary for 3Q3K
Entry DOI | 10.2210/pdb3q3k/pdb |
Related | 1V3X 1WU1 2EI6 2EI7 2EI8 3IIT |
Descriptor | Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | protein inhibitor complex, blood coaggulation, cleavage of basic residues, disulfide bond, egf-like domain, hydroxylation, protease, secreted, zymogen, glycoprotein, hydrolase, blood coaggulation factor, serine protease, gamma-carboxyglutamic acid, plasma, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 32739.64 |
Authors | Suzuki, M.,Imai, E. (deposition date: 2010-12-22, release date: 2011-12-28, Last modification date: 2023-11-01) |
Primary citation | Yoshikawa, K.,Yoshino, T.,Yokomizo, Y.,Uoto, K.,Naito, H.,Kawakami, K.,Mochizuki, A.,Nagata, T.,Suzuki, M.,Kanno, H.,Takemura, M.,Ohta, T. Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors. Bioorg.Med.Chem.Lett., 21:2133-2140, 2011 Cited by PubMed: 21345673DOI: 10.1016/j.bmcl.2011.01.132 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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