3Q3K

Factor Xa in complex with a phenylenediamine derivative

3Q3K の概要

• エントリーDOI: 10.2210/pdb3q3k/pdb
• 関連するPDBエントリー: 1V3X 1WU1 2EI6 2EI7 2EI8 3IIT
• 分子名称: Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: protein inhibitor complex, blood coaggulation, cleavage of basic residues, disulfide bond, egf-like domain, hydroxylation, protease, secreted, zymogen, glycoprotein, hydrolase, blood coaggulation factor, serine protease, gamma-carboxyglutamic acid, plasma, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32739.64

構造登録者

Suzuki, M.,Imai, E. (登録日: 2010-12-22, 公開日: 2011-12-28, 最終更新日: 2023-11-01)

• 主引用文献: Yoshikawa, K.,Yoshino, T.,Yokomizo, Y.,Uoto, K.,Naito, H.,Kawakami, K.,Mochizuki, A.,Nagata, T.,Suzuki, M.,Kanno, H.,Takemura, M.,Ohta, T.; Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.; Bioorg.Med.Chem.Lett., 21:2133-2140, 2011; PubMed: 21345673; DOI: 10.1016/j.bmcl.2011.01.132

実験手法

X-RAY DIFFRACTION (2 Å)