3Q2Z
Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid
Summary for 3Q2Z
Entry DOI | 10.2210/pdb3q2z/pdb |
Related | 3ASX 3Q30 |
Descriptor | Squalene synthase, PHOSPHATE ION, N-{[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl}-L-aspartic acid, ... (4 entities in total) |
Functional Keywords | isoprene biosynthesis, lipid synthesis, multifunctional enzyme, oxidoreductase, steroid biosynthesis, sterol biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268 |
Total number of polymer chains | 1 |
Total formula weight | 39838.69 |
Authors | Suzuki, M.,Shimizu, H.,Katakura, S.,Yamazaki, K.,Higashihashi, N.,Ichikawa, M.,Yokomizo, A.,Itoh, M.,Sugita, K.,Usui, H. (deposition date: 2010-12-21, release date: 2011-12-21, Last modification date: 2023-11-01) |
Primary citation | Ichikawa, M.,Yokomizo, A.,Itoh, M.,Sugita, K.,Usui, H.,Shimizu, H.,Suzuki, M.,Terayama, K.,Kanda, A. Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors Bioorg.Med.Chem., 19:1930-1949, 2011 Cited by PubMed: 21353782DOI: 10.1016/j.bmc.2011.01.065 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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