3Q1C

Structure of EspG Protein

3Q1C の概要

• エントリーDOI: 10.2210/pdb3q1c/pdb
• 分子名称: LEE-encoded effector EspG (2 entities in total)
• 機能のキーワード: vira fold, virulence factor, pak recruitment and activation, p21 activated kinase, signaling protein
• 由来する生物種: Escherichia coli O127:H6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39879.58

構造登録者

Spiller, B.W.,Germane, K.L. (登録日: 2010-12-17, 公開日: 2011-02-23, 最終更新日: 2024-02-21)

主引用文献

Germane, K.L.,Spiller, B.W.
Structural and Functional Studies Indicate That the EPEC Effector, EspG, Directly Binds p21-Activated Kinase.
Biochemistry, 50:917-919, 2011

PubMed Abstract: Bacterial pathogens secrete effectors into their hosts that subvert host defenses and redirect host processes. EspG is a type three secretion effector with a disputed function that is found in enteropathogenic Escherichia coli. Here we show that EspG is structurally similar to VirA, a Shigella virulence factor; EspG has a large, conserved pocket on its surface; EspG binds directly to the amino-terminal inhibitory domain of human p21-activated kinase (PAK); and mutations to conserved residues in the surface pocket disrupt the interaction with PAK.

PubMed: 21235237
DOI: 10.1021/bi1020138

実験手法

X-RAY DIFFRACTION (1.596 Å)