3PYK

Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor

Summary for 3PYK

Entry DOI	10.2210/pdb3pyk/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, chloro{N-[di(pyridin-2-yl-kappaN)methyl]-4-sulfamoylbenzamide}[(1,2,3,4,5,6-eta)-(1R,2R,3R,4S,5S,6S)-1,2,3,4,5,6-hexamethylcyclohexane-1,2,3,4,5,6-hexayl]ruthenium(2+), ... (6 entities in total)
Functional Keywords	10 stranded, twisted beta-sheets, carbonate dehydratase activity, protein binding, zinc ion binding, lyase activity, metal ion binding, co2, bicarbonate, sulfonamides, metal ions, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	30317.36
Authors	Heinisch, T.,Schirmer, T. (deposition date: 2010-12-13, release date: 2011-07-13, Last modification date: 2023-09-13)
Primary citation	Monnard, F.W.,Heinisch, T.,Nogueira, E.S.,Schirmer, T.,Ward, T.R. Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor. Chem.Commun.(Camb.), 47:8238-8240, 2011 Cited by PubMed: 21706094 DOI: 10.1039/c1cc10345h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation