3PSU

HIV-1 protease in complex with an isobutyl decorated oligoamine (symmetric binding mode)

3PSU の概要

• エントリーDOI: 10.2210/pdb3psu/pdb
• 関連するPDBエントリー: 3BGB
• 分子名称: Protease, N,N'-(iminodiethane-2,1-diyl)bis[4-amino-N-(2-methylpropyl)benzenesulfonamide], CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11364.94

構造登録者

Lindemann, I.,Heine, A.,Klebe, G. (登録日: 2010-12-02, 公開日: 2011-12-07, 最終更新日: 2023-11-01)

• 主引用文献: Lindemann, I.,Linde, K.,Sammet, B.,Heine, A.,Diederich, W.E.,Klebe, G.; Multiple binding modes of a symmetric inhibitor in HIV-1 protease; To be Published,

実験手法

X-RAY DIFFRACTION (2.07 Å)