3PS2

Crystal structure of the Escherichia Coli LPXC/LPC-012 complex

3PS2 の概要

• エントリーDOI: 10.2210/pdb3ps2/pdb
• 関連するPDBエントリー: 3PS1 3PS3
• 分子名称: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 4-[4-(3-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-nitroso-1-oxobutan-2-yl]benzamide, ... (7 entities in total)
• 機能のキーワード: lpxc, hydrolase, deacetylation, antibiotic, acyl udp-glcnac, hydroxamate, lpc-012, baab sandwich, lipid a biosynthesis, lipid a synthesis, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Escherichia coli IHE3034
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34777.97

構造登録者

Lee, C.-J.,Zhou, P. (登録日: 2010-11-30, 公開日: 2011-01-19, 最終更新日: 2024-02-21)

• 主引用文献: Liang, X.,Lee, C.J.,Chen, X.,Chung, H.S.,Zeng, D.,Raetz, C.R.,Li, Y.,Zhou, P.,Toone, E.J.; Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.; Bioorg.Med.Chem., 19:852-860, 2011; PubMed: 21194954; DOI: 10.1016/j.bmc.2010.12.017

実験手法

X-RAY DIFFRACTION (2.3 Å)