3PR2
Tryptophan synthase indoline quinonoid structure with F9 inhibitor in alpha site
Summary for 3PR2
Entry DOI | 10.2210/pdb3pr2/pdb |
Descriptor | Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total) |
Functional Keywords | alpha-beta barrel, tim-barrel, tryptophan synthesis, lyase |
Biological source | Salmonella enterica subsp. enterica serovar Typhimurium More |
Total number of polymer chains | 2 |
Total formula weight | 71926.89 |
Authors | Lai, J.,Niks, D.,Wang, Y.,Domratcheva, T.,Barends, T.R.M.,Schwarz, F.,Olsen, R.A.,Elliott, D.W.,Fatmi, M.Q.,Chang, C.A.,Schlichting, I.,Dunn, M.F.,Mueller, L.J. (deposition date: 2010-11-29, release date: 2011-02-09, Last modification date: 2024-02-21) |
Primary citation | Lai, J.,Niks, D.,Wang, Y.,Domratcheva, T.,Barends, T.R.,Schwarz, F.,Olsen, R.A.,Elliott, D.W.,Fatmi, M.Q.,Chang, C.E.,Schlichting, I.,Dunn, M.F.,Mueller, L.J. X-ray and NMR Crystallography in an Enzyme Active Site: The Indoline Quinonoid Intermediate in Tryptophan Synthase. J.Am.Chem.Soc., 133:4-7, 2011 Cited by PubMed: 21142052DOI: 10.1021/ja106555c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report