3PR2

Tryptophan synthase indoline quinonoid structure with F9 inhibitor in alpha site

3PR2 の概要

• エントリーDOI: 10.2210/pdb3pr2/pdb
• 分子名称: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total)
• 機能のキーワード: alpha-beta barrel, tim-barrel, tryptophan synthesis, lyase
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhimurium; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71926.89

構造登録者

Lai, J.,Niks, D.,Wang, Y.,Domratcheva, T.,Barends, T.R.M.,Schwarz, F.,Olsen, R.A.,Elliott, D.W.,Fatmi, M.Q.,Chang, C.A.,Schlichting, I.,Dunn, M.F.,Mueller, L.J. (登録日: 2010-11-29, 公開日: 2011-02-09, 最終更新日: 2024-02-21)

• 主引用文献: Lai, J.,Niks, D.,Wang, Y.,Domratcheva, T.,Barends, T.R.,Schwarz, F.,Olsen, R.A.,Elliott, D.W.,Fatmi, M.Q.,Chang, C.E.,Schlichting, I.,Dunn, M.F.,Mueller, L.J.; X-ray and NMR Crystallography in an Enzyme Active Site: The Indoline Quinonoid Intermediate in Tryptophan Synthase.; J.Am.Chem.Soc., 133:4-7, 2011; PubMed: 21142052; DOI: 10.1021/ja106555c

実験手法

X-RAY DIFFRACTION (1.85 Å)